Increased risk of atrial fibrillation in patients with uterine fibroids: a nationwide population-based study

Abstract Background Uterine fibroid, the most common benign neoplasm of uterus, is associated with an elevated risk cardiovascular disease. The link between incident atrial fibrillation (AF) and uterine fibroid unclear because earlier studies focused primarily on development atherosclerosis hypertension. We aimed to investigate AF in patients fibroid. Methods This a retrospective cohort study using Korean National Health Insurance Service database (NHIS). From 2009 2012, total 2,574,349 women (20 40 years old) who underwent general health examinations were included. Diagnosis fibroids surgical treatment status was defined by international classification diseases, 10th revision codes, procedural codes from NHIS. primary outcome newly diagnosed AF. according their evaluated Cox proportional-hazard models. Results Of population, mean age 29.76±4.27 years, 20,682 (0.8%) identified have Incident 3,868 (61 group, 3,807 control group) during follow-up 7.3±1.1 years. Patients group showed higher incidence compared (0.41 0.20 per 1000 person-years, respectively, Figure 1). Multivariate Cox-regression analysis presented that independent factor AF: hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.16–1.93, p=0.002. Compared tend show lower for (HR 1.22, CI 0.79–1.90) than without 1.69, 1.24–2.30), though statistical significance indeterminate (Figure 2). After propensity score matching, when 1.77, 1.32–2.63, p<0.001), which line our main results. presence consistently among all subgroups except stroke subgroup. Conclusion are predisposed increased group. Careful monitoring arrhythmia would be warranted as it modest decrement Funding Acknowledgement Type funding sources: None.